Pharmacometabolomics is a useful tool to identify biomarkers that can assess and predict response after drug administration.The primary purpose of pharmacometabolomics is to better understand the mechanisms and pathways of a drug by searching endogenous metabolites that have significantly changed after drug administration.DA-9701, a prokinetic agent, shoulder bag consists of Pharbitis seed and Corydalis tube extract and it is known to improve the gastrointestinal motility.Although the overall mechanism of action of DA-9701 remains unclear, its active ingredients, corydaline and chlorogenic acid, act as a 5-HT3 and D2 receptor antagonist and 5-HT4 receptor agonist.To determine the significant metabolites after DC Power the administration of DA-9701, a qualitative analysis was carried out using ultra-high performance liquid chromatography coupled with orbitrap mass spectrometer followed by a multivariate analysis.
Seven candidates were selected and a statistical analysis of fold change was performed over time.Our study concluded that all the seven selected metabolites were commonly involved in lipid metabolism and purine metabolism.